Scientist (f/m/d) for Translational Cancer Immunotherapy 80-100%

Preferred employment start date is 01.07.2026 (01.09.2026 at the latest)

USZ Campus

The joined research activities at the Department of Medical Oncology and Hematology of the University of Zurich and University Hospital Zurich and the Department of Oncology of University of Zurich and the Children Hospital Zurich are directed towards translating innovative immunotherapies to the clinic in the framework of the NCCR children and cancer. In this position, the successful candidate will contribute to a translational project focused on understanding the immune landscape of B-cell acute lymphoblastic leukemia (B-ALL) after CAR T-cell therapy and on developing therapeutic strategies to overcome tumor microenvironment and metabolic-driven resistance. The project combines patient-derived samples, single-cell and flow cytometry-based immune profiling, in vitro functional assays, and preclinical xenograft models to advance precision oncology approaches in cell therapy.

Your responsibilities

Working together with the team, your main duties include:

Project-specific experimental work on CAR T-cells
Processing and coordination of longitudinal patient-derived samples in collaboration with clinical partners
Design and execution of in vitro functional assays
Contribution to in vivo studies in established NSG xenograft models
Perform Immune profiling using single-cell RNA sequencing workflows
Data analysis, interpretation, presentation, and contribution to manuscripts, reports, and grant-related documents
General laboratory coordination, including ordering, organization of reagents, and maintenance of laboratory records and equipment

Your profile

The position requires a doctoral degree (PhD) with postdoctoral experience in cancer immunology, cell therapy, or a related translational field. We are looking for someone with:

A strong background in cancer immunotherapy, cell therapy, or translational tumor immunology
Hands-on experience with primary human cell culture, T-cell assays, and flow cytometry
Experience with molecular and cellular immunology methods; familiarity with single-cell technologies and/or bioinformatic analysis is an asset
Experience with preclinical in vivo models is advantageous
Excellent organizational and scientific writing skills, reliability, and the ability to work both independently and as part of a team
Very good communication skills in English

What we offer

You will work in an international, dynamic, and highly collaborative translational cancer research environment at the interface of laboratory and clinical oncology.

The laboratories are located within the University of Zurich and University Hospital Zurich premises in Zurich and the Department of Oncology of University of Zurich and the Children Hospital Zurich.

Your application

Please submit your application including CV, diplomas, and motivation letter, together with the contact information of two references, to Prof. Chiara F. Magnani (chiara.magnani@usz.ch) and Beat Bornhauser (beat.bornhauser@kispi.uzh.ch).

We look forward to receiving your application

Rahel Aggeler
Recruiting

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Über das USZ

Das Universitätsspital Zürich ist eines der grössten Spitäler in der Schweiz. Unsere über 8'600 Mitarbeitenden und rund 700 Auszubildende setzen sich täglich für das Wohl unserer Patient:innen ein.