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Postdoctoral fellow position

Research Unit, Visceral & Transplant Surgery Department, University Hospital Zürich

Your main tasks

The Department of Visceral and Transplant Surgery of the University Hospital Zürich has long-lasting interest in academic research with the ultimate aim to advance clinical treatment. Besides experimental surgery and medicine, the associated laboratories also explore fundamental questions such as the basic principles behind liver regeneration. We are seeking a postdoctoral fellow to engage in an SNF-sponsored project on the coordination of growth and metabolic tasks during liver regeneration following tissue loss. The overall aim of this project is to understand how liver can deal with the metabolic pressure acting on small remnants that must grow following resection. We have developed mouse models of liver resection (with normal, delayed, or accelerated regeneration) that may reveal the handling of metabolic tasks during divergent situations of hepatic stress. Studies on the proliferative and metabolic capacities of remnants are ongoing.

The fellow shall complement ongoing studies by a metabolomic analysis of serum and tissue - with the main goals to characterise the nature & kind of metabolites that require processing by the liver during regeneration, and to explore potential ways for the mitigation of the resulting metabolic pressure. Work with mice and in vitro organisms will be a basis. Contributions to general lab management and to manuscript/grant writing are expected, while constructive shaping of research (e.g. introduction of new techniques) is encouraged. Likewise, the fellow shall engage in the supervision of students (PhD/MSc/MD level) and interact with clinicians.

Your profile

Candidates should have a molecular biology background, hold a PhD, solid experience in metabolomics technologies and associated data retrieval, analyses, and interpretation. The position requires developed writing/communication skills (English, German an advantage), a strong interest in regenerative (patho)physiology, organisational skills, and the ability to interact with interprofessional teams from several research groups. Candidates with a pragmatic, down-to-earth approach and sound social skills will be preferred.

What we offer

• 3-year position and fully covered salary (considering experience according to the SNF), with the option of extension
• Exciting work at the intersection of basic sciences and clinical translation
• A multidisciplinary environment with close association to the UZH and ETH offering state-of-the-art facilities
• Room to engage in additional visceral studies, be it independently or in association with the corresponding group leaders
• The option to acquire own funding for independent research and to engage in further education More

Your application

Please send full application documents (motivation letter, CV, publication list, references) as a single PDF by email to both anurag.gupta@usz.ch and bostjan.humar@usz.ch

About USZ

The University Hospital Zurich is one of the leading hospitals in Switzerland. The combination of care, research and teaching makes it possible to apply the knowledge advantage for the benefit of all. Every year, our 8 500-strong workforce treats more than 42 300 in-patients and 700 000 out-patients with dignity and compassion. We provide an inspiring environment for you to apply your knowledge and skill.